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Alzheimers disease (AD) is a progressive neurodegenerative disorder, 6 the most common cause of dementia, characterized by gradual memory loss, cognitive impairment, and behavioral disturbances

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When activated, NRF2 induces the expression of key antioxidant enzymes, including superoxide dismutase, glutathione peroxidase and peroxiredoxin while simultaneously downregulating NF-B-mediated expression of pro-inflammatory cytokines (Reference Saha, Buttari and Panieri154)

Study approval All animal experiments were performed in accordance with the National Institutes of Healths Guide for the Care and Use of Laboratory Animals (NIH publication no

NAD + controls circadian reprogramming through PER2 nuclear translocation to counter aging