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Al-Shobaili, H.A., et al.,Hydroxyl radical modification of immunoglobulin g generated cross-reactive antibodies: its potential role in systemic lupus erythematosus

This concern has not been studied longitudinally even in animal models the existing preclinical studies used relatively short treatment durations

Elegant experiments revealed that much of the glutamine dependence of cancer cell lines is driven by the superphysiologic concentration of cystine in standard growth media: in these cells high cystine drives the cystine/glutamate antiporter xCT to import cystine and excrete glutamate, and the cells must then import glutamine to maintain intracellular glutamate