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Transcriptomic and unbiased metabolomic modeling in ndufs2 -/- larvae uncovered a host of dysregulated pathways and genes that may be downstream cellular effects of primary CI deficiency that significantly impact animal survival and health and thereby warrant investigation for potential therapeutic manipulation

Am J Respir Crit Care Med 176: 270276 200611-1722OC [pii];10.1164/rccm.200611-1722OC [doi]

Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

While this mechanism explains the negative impact of ablative radiation doses on abscopal responses in a murine mammary carcinoma model (Dewan et al., 2009), the observation is not consistently held up in non-abscopal readouts of tumour immunity, suggesting that other factors may be involved in this regulation (Burnette et al., 2011

doi: 10.3390/ijms23010014 119 KaY.ItoR.NozuR.TomiyamaK.UenoM.OguraT.et al