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Extensive animal and human studies have been conducted on medicinal preparations of A

These systems have demonstrated significant success across different medical sectors, including oncology, cardiology, and infectious disease management [5]

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doi: 10.1016/j.redox.2019.101171

Nevertheless, although cells transfected with a human metallothionein gene can acquire resistance to cisplatin and alkylating agents (Kelley et al, 1988), and cells that do not produce metallothionein show increased chemosensitivity (Kondo et al, 1995), there is no in vivo evidence to support a major role for metallothioneins in clinical drug resistance