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The lethality of the glr1 trr1 mutant is somewhat surprising given that this strain should still be able to synthesize GSH and thioredoxins, which are both made in the reduced form

Similar to the situation in MYC-driven cancer cells, glutamine uptake is enhanced in K-Ras-driven cells via upregulation of SLC1A5 181

When treated with anti-PD1/PD-L1 immunotherapy plus chemotherapy, female-gender NSCLC patients survive longer than their male-gender counterparts [68]

Stress exposure, particularly early-life adversity, may dysregulate endogenous ALC signaling and moderate treatment response (Figure 4)

Recent state-of-the-art review of IR, obesity and T2D