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Disruption of leukemia/stroma cell interactions by CXCR4 antagonist CTCE-9908 enhances chemotherapy-induced apoptosis in AML

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In-depth study and clarification of the pathophysiological mechanism of ferroptosis in related diseases will provide new ideas for discovering potential drug targets and clinical prevention methods

For instance, increased levels of IL-6 can upregulate MCP-1 expression in endothelial cells and macrophages, establishing a positive feedback loop that amplifies the inflammatory response (137)