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In a phase Ib study (NCT02283775) of isatuximab-Pd administered by a fixed infusion volume, 7 of 47 patients had received daratumumab in a prior line [58]

on alternate days until there is no further improvement

Defined endpoint and review

However, as Fragment 176-191 is a research chemical and in vivo testing is prohibited, there remains a paucity of published data on administration via subcutaneous injection

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