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In addition, SH-SY5Y cells treated with GHK exhibited significant increases in cell viability as well as decreases in the level of LDH release caused by hemin-induced injury

To demonstrate specificity of the effect, we sought to rescue the decreased mEPSC frequency by pretreating with pyroglutamate (PGA), the precursor of glutamate that is synthesized downstream of GGT, which is blocked by acivicin (Fig

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However, it is often associated with dryness, peeling, and irritation

This may lead to a better accessibility to the ubiquitination machinery (Supplementary Fig