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At 428.301(b)(2), we proposed to codify the policy set forth in section 40.5.1 of the revised Medicare Part D Drug Inflation Rebate Guidance to apply a greater applicable percent reduction for generic Part D rebatable drugs, which, by definition, are sole source generic drugs, compared to brand-name drugs and biologicals, including biosimilars

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doi: 10.1016/j.jfma.2012.02.022

An eligible example is the use of cobalamin supplementation to decrease the severity of chemotherapy-induced peripheral neuropathy, which concerns approximately one third of all patients undergoing chemotherapy [65]