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FIGURE 9 Discussion Nrf2 is a key member of cap-n-collar basic leucine zipper transcription factor family, and is also a key regulator of mammalian genes involved in cell protection and detoxification by preventing oxidative stress ( As the first step of metabolism, the liver is often exposed to high concentrations of exogenous and endogenous metabolites, especially vulnerable to oxidative damage caused by intermediate active substances

However, as we age or experience high levels of stress, our production of catalase and glutathione begins to dip

EMT is characterized by the downregulation of cell-cell adhesion molecules, including E-cadherin, and the upregulation of mesenchymal markers, such as SMA, fibroblast-specific protein 1 (FSP1), fibronectin, collagen, and vimentin (70)

So even though they are no longer formally restricted by Category 2, the affirmative basis to compound them at scale still doesnt exist