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Increased skin blood flow and enhanced sensible heat loss in humans after nicotinic acid ingestion

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This is accomplished through the upregulation of key SMAD proteins SMAD2, SMAD3, and SMAD5, serving as intracellular effectors of the TGF- signaling pathway, which is crucial for follicular development, oogenesis, and GCs function

Moreover, a systematic analysis of liver tissues from patients with primary hyperoxaluria revealed high rates of chronic liver disease, hepatic inflammation and fibrosis in patients with AGXT dysfunction 21

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