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Females homozygous for the 5-reductase-2 mutation have been observed to have normal development of internal and external genitalia

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Similarly, trials in which a combination of several antioxidants was administered (vitamins C, E, selegiline, selenium, and L-methionine) also failed to show any improvement in ALS patients (Orrell et al., 2008)

J Biol Chem 274 : 28662871 Gladyshev VN, Jeang KT, Stadtman TC 1996 Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion