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Double-label immunofluorescence staining showed co-localization of IL-6 with F4/80 confirming that infiltrating macrophages during CP are an important source of IL-6 production and that macrophages play a role in the progression of pancreatic fibrosis ( To investigate whether the increased macrophages in the CP pancreas are mainly M1 or M2, CD11b monocytes/macrophages were selected for gene expression analysis in a mouse CP model induced by cerulein and further validated by flow cytometry that M2 macrophages, which are mainly anti-inflammatory and promote tissue repair, were predominant in CP ( In an in vitro assay, Xue et al

Mitochondria are not only the primary source of ATP but also participate in regulating apoptosis, calcium homeostasis, ROS generation, and immune responses (Cano Sanchez et al., 2018

doi: 10.1016/j.molcel.2017.09.009 81 YangWSKimKJGaschlerMMPatelMShchepinovMSStockwellBR

Compared to traditional H 2 S salts, GYY4137 has a longer half-life, allowing for a more controlled release of H 2 S over time