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In the presence of nutrient deficiency or decreased cellular ATP levels, OPA1 tightens the arrangement of mitochondrial cristae, promotes the aggregation of ATP synthase, and increases ATP production (101)

doi: 10.3389/fphar.2023.1255501 Received 08 July 2023 Accepted 04 August 2023 Published 17 August 2023 Volume 14 - 2023 Edited by Weijie Xie, Shanghai Jiao Tong University, China Reviewed by Xiang Dong Du, Suzhou Psychiatric Hospital, China Shen Li, Tianjin Medical University, China Updates Copyright 2023 Zhao, Liu, Wang, Wang, Xiu and Li

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In another study, the treatment with acetyl-l-carnitine counteracted morphological alterations of neurons in a loose sciatic nerve ligation model and had a positive effect on myelin sheath function [16]