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Lastly, vitamin B12 supplements are incredibly safe even in large doses

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If you have the MTHFR polymorphism, you could benefit from the active form of folate (5-MTHF or methylfolate), which may be more bioavailable

Hematocrit, reticulocyte count, Vitamin B12, folate and iron levels should be obtained prior to treatment

If you start at full dose and develop a headache, you cannot tell if the peptide caused it or if you would have had that headache anyway