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Magnius L, et al

Cancer 160 ZhouZ.WangH.LiJ.JiangX.LiZ.ShenJ

2.2 Melatonin receptors and melatonergic ligands Melatonin regulates sleep and the circadian rhythm by activating two high-affinity G proteincoupled receptors, i.e., MT 1 and MT 2 ( 1 is expressed in the locus coeruleus (LC) and perifornical lateral hypothalamus (PFH), regulating the rapid eye movement (REM), while MT 2 is found in the thalamic reticular nucleus (TRN) in charge of the non-REM (NREM) activity (Waly and Hallworth, 2015)

(2009) Oxidative disassembly of the [2Fe-2S] cluster of human Grx2 and redox regulation in the mitochondria, Biochemistry , 48 , 38133815

Histological analysis further supported these behavioral findings, showing partial restoration of tyrosine hydroxylase staining in the substantia nigra of Dihexa-treated animals, indicative of neuronal protection and recovery [2]