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Anti-rheumatic properties of gentiopicroside are associated with suppression of ROS-NF-B-NLRP3 axis in fibroblast-like synoviocytes and NF-kappaB pathway in adjuvant-induced arthritis

7.4 Inflammatory network regulation and precision therapy Although PGE2 is a classic inflammatory mediator, its downstream signaling pathways through different receptors (such as EP4) may be precisely regulated to achieve anti-inflammatory and tissue repair effects

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The histone acetyltransferase inhibitor Butyrolactone 3 blocks high-glucose-induced H3K27 crotonylation, activates autophagy, and suppresses keratinocyte ferroptosis [48]

This approach helps to mitigate issues related to mixed bias and reverse causality ( 2 Materials and methods 2.1 Study design To ensure the validity of our MR analysis, we utilized instrumental variables (IVs) that satisfied three core assumptions: (i) IVs must be closely related to the antioxidant dietary characteristics of the exposure factors