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Third, meta-inflammation shares key features with para-inflammation and differs from classical inflammation by the absence of a delimited inflammatory focus with barrier function and by the preferential involvement of resident stromal cells, with emphasis on macrophage-driven remodeling rather than on massive leukocyte influx

Alternative management strategies, such as lifestyle counseling or simple reassurance, are valid medical interventions

Barrera-Vargas, A

Pharmacological or genetic activation of PINK1 stabilization and Parkin recruitment enhances mitochondrial turnover and reduces cytosolic mtDNA levels [60]

Wang M , Locke FL, Munoz J, Goy A, Holmes HE, Siddiqi T, Flinn I, McSweeney PA, Reagan PM, Hill BT, Jacobson CA, Rizzieri DA, Heffner LT, Jaglowski SM, Miklos DB, Shaughnessy P, Unabia S, Rossi JM, Jiang Y, Jain RK