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The history/physical should address signs of alternative, potentially life-threatening diagnoses, including potential neurologic etiology, acute abdominal pathology, or progressive worsening or a change from typical symptom presentation

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Some studies have indicated the presence of a small to medium sized reduction, while others have noted no differences, or higher GSH in schizophrenia ( In recent times, meta-analysis of group variance has emerged as an important method in the investigation of therapeutic ( Greater variability in GSH levels in schizophrenia would mean that some patients (i.e., the putative low-GSH subgroup) are more likely to benefit from the use of GSH precursors or drugs that activate Nrf2 pathway than the others