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Pharmacology 61 , 154166 (2000)

Symbiosis 74(3):167176

Specifically targeting lactylation without affecting other acylations is crucial for achieving therapeutic effects and avoiding unintended side effects

Additionally, PKM2 seems to play an important role in EC function and angiogenesis as silencing of PKM2 resulted in decreased sprouting (Gmez-Escudero et al., 2019), but also in reduced VE-cadherin expression resulting in destabilization of the cellular junctions (Gmez-Escudero et al., 2019)