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A.Terron ExpositoR.KalteneckerD.MorignyP.MachadoJ.et al (2021)

doi: 10.1172/JCI83657 73 LiuSPromesJAHarataMMishraAStephensSBTaylorEBet al

Adults under 60, rising to 20% in those over 60 Special flag / patients also taking metformin should monitor B12 closely due to documented depletion Key lab threshold / serum B12 0.4 mol/L) typically start with 1,000 mcg oral daily for 1 to 3 months, then reassess