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COLVI is also found abundantly in normal skin at the dermal-epidermal border, where it contributes to the near-impenetrable skin barrier to environmental exposures, as well as within skeletal muscle, the cerebral meninges, and in disease states such as glioblastoma and Alzheimers disease [20,21]

Research has consistently shown that glutathione levels decline with age and are depleted in many chronic disease states including Parkinson's disease, liver disease, heart disease, and alcohol use disorder

Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction