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Alloferon has immunomodulatory and antiviral effects in people infected with human papillomavirus and herpes simplex virus, indicating that this peptide has therapeutic potential (51)

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It is estimated up to 10% of all IEC gene transcriptions are modulated by commensal species in the gut lumen, many of which are involved in controlling immunological, metabolic, and cellular proliferative pathways (Sommer et al

They combined this targeting sequence with a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes when internalized by cells