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The development of multiagonists, including GLP-1glucagon and GIPGLP-1glucagon receptor agonists, especially with the potential for glucagon receptor activation, marks a significant advancement in the field

moderate quality evidence) (Samimi et al., 2016), LDL level in one group (MD 0.33, 95% CI [0.050.71]

Mitochondrial dysfunction may further promote the release of Fe, intensifying the Fenton reaction and generating more OH, thereby amplifying intracellular oxidative stress