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Food Sci Nutr 12:6660 Lind AL, Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rokas A (2017) Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

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In a four-week, placebo-controlled study, participants who took 100200 mg/daily of Pycnogenol had significant reductions in redness of the skin due to inflammation, compared to those taking a placebo