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The movement of bacteria and/or their cell wall components is linked to hyperglycemia and increased gut permeability, which triggers an inflammatory process linked to obesity and insulin resistance (Thaiss et al., 2018)

The combination of choline kinase- inhibitor MN58b and AMPK agonist metformin could reduce synovial vascular opacification area by 43% through dual inhibition of phosphatidylcholine synthesis and glycolytic enzyme expression ( Current research has explored the combined application of HK2 inhibitors (e.g., 2-DG) and AMPK agonists (e.g., Metformin) in RA models, demonstrating synergistic inhibitory effects on synovitis and bone erosion

, 2020, vol

Adv Skin Wound Care

Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome