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Importantly, the notochord is the main signaling center that directs the patterning of the surrounding tissues during early development (Pourqui et al., 1993

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Metabolism of all ECs is characterized by a reliance on glycolysis for ATP generation in both proliferating and quiescent states, with a notable decrease in glycolytic flux during quiescence (De Bock et al, 2013b

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Experimental models have examined its influence on vascular endothelial growth factor receptor-2 (VEGFR2) signaling, including activation of downstream VEGFR2AkteNOS pathways associated with endothelial cell proliferation and vascular signaling processes