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This is correlated with the further increase in tissue NAD + levels 24

Other conditions that make Vitamin B12 absorption more difficult are: Weight loss surgery or another operation that removed part of your stomach Heavy drinking Taking acid-reducing medication for a long time Certain health issues may also lead to the development of vitamin B12 deficiency such as atrophic gastritis, pernicious anemia, Crohns disease, celiac disease, immune system disorders, Graves disease and lupus

In smaller, less well controlled studies levels for men and women have been similar, irrespective of age (de Carvalho et al., 1996

It reduces methylmalonic acid (MMA) levels in the body, an acid that can prevent normal fatty acid synthesis and lead to severe damages to the nervous system over time