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In the challenge test, in accordance with the assumptions of the PN-EN ISO 11930:2019 standard, nephelometric-calibrated suspensions of test microorganisms (N) with a density in the range of 1 10 7 1 10 8 unit/ml for bacteria and 1 10 6 1 10 7 unit/ml for fungi were used to contaminate the test samples

The delayed-release formula is intended to reach the lower intestines without succumbing to the harsh environment of the upper digestive system.* Historically, peptides have been notoriously difficult to absorb orally

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This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation

Nature 510, 542546