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Thus, it was possible for both the proximal and distal obstructions to be bypassed by an additional vessel network running between the arcades (outside-inside ligation, outside-inside, inside-inside and inside-outside) at both the ventral and dorsal sides of the colon

While encouraging, this studys retrospective design, lack of placebo control, small sample size, and subjective outcome reporting limit its interpretability

12 As a consequence, dehydration of the nucleus pulposus (NP) occurs with subsequent reduction of disc height and shock-absorbing capacity, thus leading to transmission of circumferential forces to the annulus fibrosus (AF) eventually resulting in AF tears which predispose to discogenic LBP, herniations and further degenerative changes

Diabetes 116 , 600605 (2008)

Peptide-based approaches can target both types of tolerance