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Dabigatran is a P-gp substrate but is not metabolized by CYP3A4, so the pharmacokinetic concern would be limited to P-gp

However, despite this radically different composition, the cellular uptake by HeLa cells was not substantially different among the particles separated using the two techniques, perhaps due to the dissociation of soft corona after dilution of NPs before the treatment

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Next, we measured the mitochondrial oxygen consumption rate (OCR) under both normoxic and hypoxic conditions in the cybrids, as OCR is a key indicator of mitochondrial function