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The glutamate and cysteine can then feed into the GCL enzyme, however, in many cases, the enzyme is not functioning optimally or is damaged in some way, so it cannot increase the amount of Glyteine available for glutathione synthesis

As expected, a marked increase in ROS production was observed in the GK rat liver and kidney, with the increase more pronounced in the liver (72%) compared to the kidney (26%)

Extracted ion chromatogram for target glycopeptides (EEQYNSTYR and the miscleaved TKPREEQYNSTYR with all different glycan masses) were extracted with 10 ppm accuracy and MS/MS spectra were manually verified

For example, elevated ROS levels can trigger the assembly of NLRP3 inflammasomes, promote mPTP opening and initiate caspase-mediated apoptosis