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Similarly, Jia et al (91) reported that elevated neuronal lactate uptake augments ROS production and mitochondrial oxidative metabolism, thereby disrupting the balance between ROS generation and detoxification, impairing ATP synthesis and ultimately leading to peripheral axonal degeneration

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Normally, GSH predominates over GSSG by a factor of 100 in the cytosol

Supporting this concept, total glutathione concentration appears to declines with aging, as demonstrated in both rat models of aging and in human aging (particularly after age 45 in humans), possibly due to a reduced ability to synthesize GSH

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