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It is important to note that all current evidence derives from in vitro cellular models and in vivo animal studies, and no human clinical trials have been conducted as of February 2026

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(6) Heike Stier, Evert Vos, David Kenley (2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans Journal of Endocrinology and Metabolism, 2013, Volume 3 (Issue 1-2), Pages 7-15

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Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1)

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