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Starting at 50mg for 7 days allows baseline NNMT activity to decline gradually, minimizing the metabolic shock of sudden substrate shift

Fishbane reaction : most commonly seen as chest discomfort, it is often self limiting

Ann Allergy Asthma Immunol

Efficacy and safety of co-administered once-weekly cagrilintide 24 mg with once-weekly semaglutide 24 mg in type 2 diabetes. Lancet 402(10403):720730

With these robust findings, CagriSema has the potential to be the first amylin and GLP-1 combination therapy that addresses blood glucose control with reductions in bodyweight for people living with type 2 diabetes." Amylin, a pancreatic hormone co-secreted with insulin in response to food intake, plays a distinct yet complementary role to GLP-1, with potential roles in appetite, glycemic control, bone metabolism, and bodyweight