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In recent years, the toxicity of natural drugs has attracted widespread concerns around the world, especially for inappropriate dosage or overdose use

The activity of these enzymes also leads to the formation of 12-hydroxyheptadecatrienoic acid (12-HHTrE), which does not contain the prostanoic acid structure [108]

High levels of oxidative stress can lead to inflammatory conditions (diabetes, cardiovascular disease and autoimmune disease) and illnesses such as cancer

Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, et al

Glutathione Peroxidase 4-catalyzed Reduction of Lipid Hydroperoxides in Membranes: The Polar Head of Membrane Phospholipids Binds the Enzyme and Addresses the Fatty Acid Hydroperoxide Group toward the Redox Center