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(9) Rudolphi B, et al

Some clients schedule weekly sessions

In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

It directly neutralizes reactive oxygen species (ROS) generated by the mitochondrial respiratory chain, regenerates oxidized vitamins C and E, and catalyzes the conjugation of xenobiotics via glutathione S-transferase (phase II detoxification)

But clinical data, dosing, and understanding of the broader effects in humans lacks study