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10.1523/JNEUROSCI.0419-16.2016 243 YuanY.HuangX.MiddeN

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

DIRECTIONS: Apply enough to lightly cover your entire face, gently tapping into the skin

Third, dosing protocols used in research settings may not perfectly replicate the carefully controlled conditions of clinical trials

The method of claim 16, wherein said one or more HGF mimics is administered with a pharmaceutically acceptable excipient