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It also emphasizes the critical need to improve the safety and efficacy of drugs through innovative drug development techniques, such as selective inhibitors, 67 dual-target inhibitors, 68,69 allosteric modulators, 70,71 covalent inhibitors, 72 proteolysis-targeting chimeras (PROTACs) 73 and protein-protein interaction (PPI) modulators, 74,75 aiming for more effective clinical translation from outcomes of research

Hypersensitivity to any drug components, acute cardiac conduction abnormalities, acute decompensated heart failure

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In RN, the initial renal cell injury, which may start the cascade towards CKD, are DSB of the DNA through ionizing radiation, either by direct ionization events in the DNA or indirectly via mediation of water ionization products and/or reactive oxygen species [61] (Fig