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Impairments in neuronal survival mediated by HMGB1 are believed to be closely associated with the glycolytic pathway, as evidenced by the mitigation of these adverse effects through treatment with the glycolysis inhibitor 2-DG [194]

Endogenous oxalate production in primary hyperoxaluria type 1 patients

She was initiated on maralixibat chloride 190 mcg/kg orally, once daily starting days 1-7, then increased to 380 mcg/kg orally, once daily starting day 8 and thereafter

Loss of the neurotransmitter dopamine, due to the degeneration of dopaminergic neurons in the midbrain underlies the pathophysiology of the motor dysfunction

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