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Most solid tumors are plugged into the systemic circulation through the stroma , a mixture of non-malignant cells pertinent -but not limited- to the hosting tissue such as fibroblasts, nerve and immune cells, blood vessels, extracellular matrix proteins and adipocytes 20 , representing up to 90% of tumor mass 21

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

Additionally, crocin showed other interactions including pi-alkyl interactions with Phe161, which contributed to its strong binding stability (Fig

The ROS levels were measured with a kit (Beyotime Biotechnology), and 2,7-Dichlorodihydrofluorescein diacetate was used to incubate the cells and then examined by microplate reader