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The criteria included assessment of shrinking, exhaustion, weakness, slowness, and low physical activity

These findings suggest that the immune system misidentifies self-antigens, which in turn drives the production of pathogenic autoantibodies [30]

Kupffer cells along with liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs), and local immune cells, specifically unconventional T cells, natural killer (NK) cells, and hepatic dendritic cells make up the nonparenchymal liver cells, which are significant chemokine sources and responders

Clinical laboratory tests Hormonal and biochemical assessments were carried out for all patients participating in the study in the Royan Institute laboratory