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A neurotransmitter produced by gut bacteria modulates host sensory behaviour

The scientific basis for peptides in promoting muscle growth lies in their ability to directly affect muscle at the molecular level, often targeting receptors on cells or increasing hormonal levels, says Major Brandon Roberts, Ph.D., C.S.C.S

A GPR56-targeted antibody-drug conjugate (ADC) in preclinical study utilizing duocarmycin SA, a DNA minor-groove alkylating agent, demonstrated target-dependent tumor growth inhibition in CRC xenografts and patient-derived organoids with acceptable tolerability (90, 93)

Emerging studies from our group and others uncovered oxalate metabolism commonly dysregulated in MASLD and cardiovascular disease 12,15,24,25,26,65