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RF recognizes the Fc domain of IgG4 and forms the RF-IgG4 immune complex, which may activate the complement system and cause synovial damage, with a pathogenic effect in RA

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Key tests include: Optical Coherence Tomography (OCT) This non-invasive scan provides detailed cross-sections of the retina, allowing us to assess thinning, drusen, and other changes in the macula over time

Not only histological findings were present, but treatment also brought recovery to forelimb function, as shown in Figure 2

While chemical inhibition of MAT2 has been shown to suppress antibody production (Ishii Y et al, submitted), it has remained unclear whether the critical enzymatic activity of MAT2 is executed in the cytoplasm or the nucleus, and its specific function within the tightly regulated molecular cascade of CSR has not been elucidated