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In two of the studies, nerve conduction velocities were evaluated using standard techniques, as described by Kimura,(15) at room temperature.(10,12) Farvid et als study measured neuropathy symptoms using the MNSI questionnaire, which generated total scores before and after intervention.(10) In Yaqub et als study, individual components of the Peripheral Neurology Symptom (PNS) score were used to assess somatic symptoms, autonomic symptoms and clinical signs.(12) In Fonseca et als study, symptoms and disability were assessed using the 6-item Neuropathy Total Symptom Score (NTSS-6) and the Neuropathy Disability Score, respectively.(11) All the studies analysed outcomes relating to VPTs or nerve conduction velocities

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Cramps refer to sudden, involuntary, and often painful contractions of the muscles

In parallel, we employed a more labor-intensive, candidate-based RNAi screen in vivo to determine whether reduced expression of individual kinases impaired NHR-49 associated phenotypes