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We test as needed after that

The IGFBP-related proteins share some structural similarities with the six IGFBPs but have no relevant impact on IGF bioactivity

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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

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