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5 Molecular interactions between amyloid, tau and mitochondrial failure 5.1 Amyloid -induced mitochondrial toxicity The accumulation of insoluble A in Alzheimer's disease results from a fundamental imbalance between peptide synthesis and clearance

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The outer membrane is traversed with porins (voltage-dependent anion channel [VDAC]) and is permeable to small molecules

Studies by [281] and [66] demonstrated that heavy coffee consumption (5.4 cups/day) in the afternoon or evening reduced the nightly peak in melatonin (the hormone of darkness) secretion by 30% compared to controls

Participants were administered two tablets each day (containing 154 mg of rhodiola and 15 mg of saffron per tablet) for a duration of 6 weeks