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After 10 weeks, the melanin index on the skin treated with the lotion containing Glutathione had decreased compared to the initial levels, while the skin treated with the placebo lotion showed little to no change

doi: 10.1182/blood-2004-05-1699 7 FanJKamphorstJJMathewRChungMKWhiteEShlomiTet al

Additionally, glycine treatment was found to alleviate ER stress caused by homocysteine by reducing the protein levels of glucose-regulated protein 78 (GRP78) and C/EBP family homologous protein (CHOP) within endothelial cells [32]