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However, compared to other neurotransmitter systems, its in-vivo assessments pose several challenges ( in vivo technique and having an excellent safety profile ( Due to conformational issues and the difficulty of utilizing brain-penetrating ligands for amino acid receptors, there has been little advance in developing radiotracers for ionotropic glutamate receptors, with the exception of the NMDA receptor (GluN2B subunit ligand)

Jul 11 2018;23(7)doi:10.3390/molecules23071684 Wiciski M, Socha M, Walczak M, et al

This apparent safety in rodents spanning 30+ years of research from multiple independent laboratories is genuine

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