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De werkzaamheid van Pickart en Margolina (2018, DOI: 10.3390/ijms19041987) toonde via transcriptomische analyse dat GHK-Cu de expressie van meer dan 4.000 genen moduleert, waaronder genen betrokken bij weefselherstel, ontstekingsprocessen en collageensynthese

Zhang H, Sun SC

This is either due to mutations in genes encoding the NF-B transcription factors themselves or in genes that control NF-B activity (such as IB genes)

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Theoretical concerns: Because DSIP interacts with the opioid system and ACTH axis in animal models, chronic use could theoretically affect neuroendocrine regulation